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Updated: Jun 17, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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由TCF12调节的GRB7通过激活Notch1信号通路来促进HER2+乳腺癌的进展

Gang Wang1,2,3, Yuanli Wu1,2,3, Yue Su1,2,3

  • 1Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.

Journal of translational medicine
|August 7, 2024
PubMed
概括

增长因子受体结合蛋白7 (GRB7) 在人类表皮生长因子受体2-阳性 (HER2+) 乳腺癌 (BC) 中被上调,促进瘤进展. 抑制GRB7抑制了瘤生长,表明其作为HER2+BC的治疗点的潜力.

关键词:
乳腺癌 乳腺癌 乳腺癌在EMT中,EMT是EMT.GRB7 GRB7 GRB7 GRB7 GRB7 GRB7 GRB7 GRB7 GRB7 GRB7 GRB7 GRB7在HER2+的基础上,HER2+在TCF12中,

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