血清甲状腺刺激激素与中国成年人正常甲状腺功能骨矿物质密度的相关性
Jia Chen1, Lidong Hu2, Ning Li3
1Department of Endocrinology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Nutrition & metabolism
|August 7, 2024
概括
甲状腺刺激激素 (TSH) 与中国成年人骨矿物质密度 (BMD) 有不同的关联. 在60岁以下的女性中,较高的TSH与较低的BMD相关,而在老年女性中,较高的TSH与较高的BMD相关.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 老年医学 老年医学
背景情况:
- 甲状腺功能,特别是血清甲状腺刺激激素 (TSH) 水平,在骨代谢中起作用.
- 了解正常TSH水平与骨矿物质密度 (BMD) 之间的关系对于评估骨健康至关重要,特别是在老龄化人口中.
研究的目的:
- 为了研究血清TSH水平和中国成年人正常甲状腺功能的骨质量之间的关联.
- 探索这种关联中的潜在的年龄和性别依赖差异.
主要方法:
- 参与者根据血清TSH水平被分为三分之一.
- 使用线性回归和多项逻辑回归模型来分析连续和分类的BMD和血清TSH之间的关联.
主要成果:
- 在60岁以下的女性中,随着TSH在正常范围内增加,BMD下降 (β=-4.34,P<0.001).
- 在60岁以上的女性中,随着TSH在正常范围内增加,BMD增加 (β=2.04,P=0.041).
- 在男性中,随着正常TSH水平的增加,不论年龄,BMD都会下降.
结论:
- 血清TSH表现出与BMD相反的趋势,在年轻女性和老年女性中,甲状腺功能正常.
- 在年轻女性和老年女性之间,TSH可能在骨代谢中起着不同的作用.
- 这种年龄相关的趋势在男性中并不显著.
更多相关视频
06:59Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
2.3K
03:56Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
Published on: April 26, 2024
564
相关概念视频
Functions of Thyroid Hormones
2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.6K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
Skeleton and Calcium Homeostasis
4.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.4K
Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
Synthesis and Functions of Calcitonin
1.7K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.7K
