相关实验视频

Updated: Jun 17, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

高温料对肠道微生物群和MAFLD的影响

Lijun Xue¹, Kaimin Li², Yanfei Jia³

¹Digestive Department 2, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, P.R. China.

Journal of microbiology and biotechnology

|August 8, 2024

概括

高温加工的食物,如干大豆,可以导致非肥胖个体的脂肪肝. 与饮食相关的肠道细菌变化会影响肝脏健康,这表明在代谢改变的肝脏疾病 (MAFLD) 中,针对微生物群的干预措施.

科学领域:

* 胃肠病学胃肠病学
* 肝病学肝病学是一门学科.
* 微生物学微生物学

背景情况:

* 代谢改变的脂肪肝疾病 (MAFLD) 越来越多地被认可,即使在非肥胖个体中也是如此.
*饮食模式,特别是那些涉及高温加工食品的饮食模式,被怀疑是MAFLD的贡献者.
*肠道微生物群在代谢健康和肝病中的作用是一个正在积极研究的领域.

研究的目的:

* 调查干大豆 (DFS) 饮食对非肥胖MAFLD模型中的肠道微生物群和代谢途径的影响.
* 探索特定的肠道微生物变化与肝脏健康指数之间的关系.
* 评估针对肠道微生物群的饮食干预措施在管理MAFLD方面的潜力.

主要方法:

* 建立了三组雄性斯普拉格-道利大鼠:对照,DFS饮食和高脂肪饮食 (HFD).
*为期12周的养研究,随后进行全面的物理,生化,组织学和微生物学分析.
*对肠道微生物群组成的分析,重点关注Akkermansia和Mucispirillum等关键属.

主要成果:

* DFS和HFD饮食都诱导了肝脏中明显的病理异常.
* DFS饮食与脂肪肝的发展和肠道微生物群的显著改变有关.
* 特定的肠道细菌,包括Akkermansia和Mucispirillum,与肝脏健康指标有很强的相关性.

结论:

*饮食诱导的肠道微生物组失调显著导致非肥胖MAFLD的肝脏病理.
*像DFS这样的高温加工食品可以促进MAFLD的发展.
*通过饮食干预来准肠道微生物群,有望为MAFLD的管理和预防提供希望.

关键词:

与代谢相关的脂肪肝疾病.便植物的特征便植物的特征高温加工加工的高温加工料非肥胖的代谢相关脂肪肝疾病的发病因子.斯普拉格 - 达威利老鼠

更多相关视频

Author Spotlight: Advancing Intestinal Bacteria Cultivation for Poultry

Author Spotlight: Advancing Intestinal Bacteria Cultivation for Poultry

Published on: May 10, 2024

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

相关概念视频

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

What is Monogastric Digestion?

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...