单独用于人类乳头瘤病毒相关的口腔关癌的低分离放射治疗
Allen M Chen1, Jeremy P Harris1, Tjoson Tjoa2
1Department of Radiation Oncology, University of California, Irvine, Chao Family Comprehensive Cancer Center, Orange, California, USA.
Head & neck
|August 8, 2024
概括
单独的低分离辐射疗法显示了人类乳头瘤病毒 (HPV) 阳性口腔癌的优异生存率和控制率. 这种方法为患有这种特定类型癌症的患者提供了有希望的结果.
科学领域:
- 辐射瘤学 辐射瘤学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
背景情况:
- 口腔癌通常与人类乳头瘤病毒 (HPV) 感染有关.
- 治疗的进步对于改善HPV阳性口腔癌的结果至关重要.
- 低分离辐射疗法是一种不断发展的治疗方式.
研究的目的:
- 评估低分离辐射疗法作为HPV阳性口癌的独立治疗方法的疗效和安全性.
- 报告来自单一机构经验的结果.
主要方法:
- 对101名患有p16阳性口腔状细胞癌的患者进行了回顾性分析.
- 治疗涉及单独的辐射疗法与两个低分离方案:66 Gy在30个分数或70 Gy在33个分数.
- 患者队列中包括很大一部分从未吸烟者 (67%).
主要成果:
- 优秀的三年精算率:94%的整体存活率,93%的局部区域控制率和89%的无进展存活率.
- 在从未吸烟者中获得更好的结果:98%的3年整体存活率和100%的局部区域控制.
- 在21%的患者中观察到3级+急性毒性,主要是粘膜炎.
结论:
- 单独的低分离辐射疗法在HPV阳性口腔癌中表现出极好的疗效.
- 这些发现支持使用这种低分离疗法来治疗HPV阳性口腔癌.
- 目前正在进行一项前性临床试验,以调查这种模式的降级策略.
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