过早分娩的代际关联:系统性审查和元分析
Abdulbasit Seid1, Miranda S Cumpston1, Kedir Y Ahmed2
1School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
概括
一个家庭有过早分娩的病史显著增加了妇女过早分娩的风险. 对这种病史的查对于识别风险妊娠和确保更密切的监测至关重要.
科学领域:
- 生殖健康和产科生殖健康和产科
- 遗传学和代际健康
- 围产期流行病学 围产期流行病学
背景情况:
- 过早出生 (PTB) 仍然是新生儿发病率和死亡率的主要原因,大约50%的病例缺乏可识别的原因.
- 关于PTB风险代际传播的现有研究在影响大小和方向方面提出了不一致的发现.
研究的目的:
- 进行系统性审查和元分析,以巩固有关早产代际关联的证据.
- 提供关于父母和家庭PTB病史如何影响后续PTB风险的综合数据.
主要方法:
- 在MEDLINE,Embase和产妇和婴儿护理数据库中进行系统的文献搜索,截至2024年4月4日.
- 包括16项包括2,271,612名母亲的研究,重点关注生物父母的PTB家族史.
- 通过两个独立的审查员提取数据,并使用随机效应模型进行元分析,以计算聚合赔率比率 (OR).
主要成果:
- 那些自己早产的女性,早产的几率增加了1.44倍 (OR = 1.44,95% CI: 1.34,1.54).
- 有一个早产的兄弟姐妹与早产的几率增加1.53倍有关 (OR = 1.53,95% CI:1.24,1.87).
- 伴侣早产与早产的几率增加了1.12倍 (OR = 1.12,95% CI: 1.01,1.25).有伴侣早产与早产的几率增加了1.12倍.
结论:
- 一个积极的早产家族史是一个重要的风险因素,以后的早产.
- 建议对孕妇进行例行查,以查看家庭史上的早产.
- 在怀孕期间,被确定具有阳性家族病史的个体需要加强监测和更密切的临床随访.
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