SGLT2 抑制剂和结石风险:一个元分析
Mehmet Kanbay1, Crischentian Brinza2,3, Sidar Copur4
1Department of Medicine, Division of Nephrology, Koç University School of Medicine, Istanbul, Turkey.
概括
-葡萄糖共载体2 (SGLT2) 抑制剂可降低结石或结石的风险. 这一元分析表明,与安慰剂或活性治疗相比,SGLT2抑制剂治疗与结石发病率较低有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- -葡萄糖共运输体2 (SGLT2) 抑制剂是一种抗糖尿病药物.
- 这些药物对心血管和的结果,代谢参数和体重有有益影响.
- 新兴研究探讨了它们对结石 (结石) 发育的影响,这种疾病影响10%的人口,并带来损伤的风险.
研究的目的:
- 系统地审查和元分析SGLT2抑制剂治疗与结石病风险之间的关联.
- 为了比较SGLT2抑制剂治疗患者与对照组 (安慰剂或活性疗法) 治疗结石的发病率.
主要方法:
- 在多个数据库 (PubMed,Ovid MEDLINE,Web of Science,Scopus,Cochrane Library) 中进行了全面的文献搜索.
- 遵循了系统审查和元分析指南 (PRISMA).
- 来自六项临床试验的数据,包括11,635,698名患有结石病的患者,被纳入分析.
主要成果:
- 在SGLT2抑制剂组中的1.27%患者发生了结石,而在对照组中为1.56%患者.
- 与安慰剂相比,SGLT2抑制剂治疗与结石病的风险显著降低 (OR 0.61,P < .00001).
- 与GLP-1和DPP-4抑制剂等活性疗法相比,也观察到降低风险 (OR 0.66,P = .02).
结论:
- 用SGLT2抑制剂治疗与结石病的风险降低有关.
- 潜在的机制包括透性尿液,降低了石化物质度,抗炎/抗纤维效应和尿液pH的增加.
- 需要进一步的大规模随机临床试验来证实这些发现并阐明机制.
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