在健康人群中使用跨骨多普勒超声波的神经血管合方法:系统性审查和共识协议
James D Ball1, Eleanor Hills1, Afzaa Altaf1
1Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
概括
本综述突出了评估神经血管合 (NVC) 的跨骨多普勒超声波 (TCD) 方法中的不一致性. 在健康的成年人中,标准化协议对于可靠的脑血流 (CBF) 测量至关重要.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 身体生理学 身体生理学
背景情况:
- 神经血管合 (NVC) 将大脑活动与大脑血流 (CBF) 变化联系起来.
- 跨骨多普勒超声波 (TCD) 用于通过任务激活协议来评估NVC.
- 在TCD研究中的方法异质性阻碍了NVC的交叉研究比较.
研究的目的:
- 总结和比较基于TCD对健康成年人的NVC评估的现有方法.
- 确定影响基于TCD的NVC测量的可靠性和意义的因素.
- 为NVC评估提供优化TCD协议的建议.
主要方法:
- 在主要数据库 (Medline,Scopus,科学网,EMBASE,CINAHL) 进行系统的文献搜索.
- 包括在健康成年人中使用TCD进行NVC评估的研究.
- 研究结果的叙述综合和包含的研究的质量评估.
主要成果:
- 76项涉及2697名参与者的研究符合审查标准.
- 在参与者位置,TCD设备和脑动脉无声化方面观察到显著的异质性.
- 最佳的NVC反应与坐姿,更长的基线记录,受控环境和验证的协议有关.
结论:
- 标准化TCD协议对于准确和可比的NVC评估至关重要.
- 特定的方法选择 (例如,参与者位置,船只选择) 影响NVC响应的大小.
- 需要进一步的研究来优化基于TCD的NVC评估,特别是在患者群体中.
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