复发性静脉血栓塞栓症和阴道雌激素在女性之前的静脉血栓塞栓症:一个嵌套的病例控制研究
Camilla Eckert-Lind1,2, Amani Meaidi3, Brian Claggett4
1Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
European journal of haematology
|August 8, 2024
概括
在先前有静脉血栓塞栓症 (VTE) 的女性中使用阴道雌激素不会增加复发静脉血栓塞栓症的风险. 这项研究表明,阴道雌激素治疗对于有VTE病史的女性是安全的.
科学领域:
- 生殖健康 生殖健康
- 心血管健康 心血管健康
- 药物监督 药物监督 药物监督
背景情况:
- 静脉血栓塞栓症 (VTE) 是女性的重大健康问题.
- 阴道雌激素治疗的安全性,特别是雌激醇,在女性有VTE病史需要澄清.
- 之前的研究没有最终评估与阴道雌激醇使用相关的复发性静脉瘤风险.
研究的目的:
- 评估阴道雌醇使用与在有史以来VTE的女性中复发VTE的风险之间的关联.
- 为了确定不同的阴道雌醇使用模式 (当前,之前,过去) 是否会影响复发性静脉瘤风险.
主要方法:
- 进行了一项全国性的嵌套病例控制研究.
- 包括45岁或以上的女性,首次患有静脉动脉突发症,且以前没有使用过阴道雌激素.
- 患有复发性VTE的病例与对照病例相匹配,并且根据与索引事件相对的时间来对阴道雌激醇的暴露进行了分类.
主要成果:
- 该研究确定了5066例复发性VTE和10,127个匹配的对照.
- 完全调整后的分析显示,阴道雌醇使用与复发性静脉瘤之间没有统计学上显著的关联.
- 目前,之前和过去使用的危险比分分别为0.75 (p=0.07),0.83 (p=0.13) 和1.24 (p=0.06).
结论:
- 在有VTE史的女性中,阴道雌激醇片的使用与复发性VTE的增加率无关.
- 这些发现表明,阴道雌醇治疗不太可能提高这种患者群体中复发性静脉瘤的风险.
- 这项研究提供了证据,支持阴道雌激素在先前患有VTE的女性中安全使用.
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