怀孕期间母体SARS-CoV-2感染对胎儿发育的影响
Jianan Li1, Jingwen Yao1, Zeyu Yang1
1Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
概括
严重急性呼吸道综合征冠状病毒 (SARS-CoV-2) 感染在怀孕期间可以通过垂直传播影响胎儿发育和结果. 需要进一步的研究来理解机制,并开发针对不良妊娠结果的干预措施.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 传染性疾病 传染性疾病
背景情况:
- 2019年严重急性呼吸系统综合征冠状病毒 (SARS-CoV-2) 爆发促使对其对怀孕和胎儿发育的影响进行调查.
- 了解SARS-CoV-2对母亲和胎儿健康的影响至关重要.
研究的目的:
- 审查有关怀孕期间SARS-CoV-2感染对胎儿结果的影响的现有文献.
- 综合有关母体SARS-CoV-2感染及其对胎儿发育的影响的证据.
主要方法:
- 自COVID-19爆发以来出版的文学作品的叙事评论.
- 在PubMed和Web of Science数据库中进行了搜索.
主要成果:
- SARS-CoV-2 可以垂直传播,影响母胎免疫接口和胎盘功能.
- 母亲的SARS-CoV-2感染与死产和早产的风险增加有关.
- 潜在的影响包括中枢神经系统的损伤,呼吸,免疫和内脏系统的变化.
结论:
- 怀孕期间的SARS-CoV-2感染通过垂直传播影响胎儿发育,并可能产生短期和长期后果.
- 机制可能涉及免疫反应,表观遗传变化和胎盘功能障碍.
- 进一步的长期研究对于指导干预和改善妊娠结果至关重要.
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