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Updated: Jun 17, 2025

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建模二种类型的 рибофлавин载体缺陷:从iPSC衍生的运动神经元到iPSC衍生的天体细胞

Valentina Magliocca1,2, Angela Lanciotti3, Elena Ambrosini3

  • 1Molecular Genetics and Functional Genomics, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.

Frontiers in cellular neuroscience
|August 8, 2024
PubMed
概括

riboflavin 载体缺陷 2 型 (RTD2) 不会影响星球细胞的发育或存活. 来自RTD2 iPSCs的星体细胞表现出正常的形态和活力,与之前研究的神经元不同.

关键词:
星球细胞是星球细胞.在体外疾病建模的模型.诱导多能干细胞的诱导干细胞.发动神经元是发动神经元.神经退行性自体衰退性疾病氧化还原状态 氧化还原状态riboflavin 携带体缺乏症 riboflavin 携带体缺乏症

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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