与健康对照人群相比,膀癌患者的压力负担增加和皮电反应性增加
I Mikolaskova1, M Zvarik2, P Hesko3
1Institute of Immunology, Faculty of Medicine, Comenius University in Bratislava, Odborarske Namestie 14, 811 08, Bratislava, Slovakia.
Heliyon
|August 8, 2024
概括
与健康人群相比,膀癌患者表现出较高的生理应激反应,包括心率升高和电皮活动. 这些压力标志物表明自主神经系统的失调,这对于管理癌症患者的福祉至关重要.
科学领域:
- 身体生理学 身体生理学
- 在瘤学瘤学.
- 心脏病学 心脏病学
背景情况:
- 自主神经系统 (ANS) 失调越来越被认为是癌症患者健康的一个因素.
- 了解膀癌 (BCa) 的生理应激反应对于患者护理至关重要.
研究的目的:
- 为了比较BCa患者与健康个体的生理压力参数.
- 为了研究 ANS 活动在轻度生理负荷期间的转变 (卧卧坐过渡).
- 探索生理压力标志物与感知压力之间的相关性.
主要方法:
- 评估了非线性心率变化 (HRV) 参数 (0V%, 2UV%),副交感 (PNS) 和交感神经系统 (SNS) 指数,心率加速/减速能力 (ACmod, DCmod),心率 (HR) 和皮电活动 (EDA).
- 测量了躺姿向坐姿过渡期间的变化.
- 与感知压力得分相关联的生理数据.
主要成果:
- 与健康对照组 (n=47) 相比,BCa患者 (n=38) 的休息HR,SNS指数和EDA都高于健康对照组 (n=47).
- 0V%的HRV参数与SNS指数,ACmod,HR和EDA正相关,与PNS指数,DCmod和2UV%负相关.
- BCa患者对位置变化表现出更强的EDA反应,表明压力反应性和ANS敏感性增加,而不管感知到的压力水平如何.
结论:
- BCa患者表现出显著的生理压力负担和ANS调节障碍.
- 非线性HRV参数为自主调节的复杂性提供了有价值的见解.
- 识别患有ANS失调风险的患者对于制定有针对性的压力管理策略至关重要.
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