在Universitas学术医院的透析患者中以多种耐药生物殖民化
Godknows Shamhuyashe1, Nicoline van Zyl2, Cornel van Rooyen3
1Department of Internal Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Southern African journal of infectious diseases
|August 8, 2024
概括
在南非透析患者中,多药耐药生物体 (MDRO) 殖民是普遍存在的,这构成了严重的感染风险. 加强感染控制措施至关重要,以应对这种高携带率.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 有限的数据存在于南非透析患者的多药耐药生物体 (MDRO) 殖民.
- 大多数MDRO感染发生在被殖民的个体中,强调了解殖民流行的重要性.
研究的目的:
- 确定在南非透析患者中MDRO殖民的流行率.
- 描述孤立的MDROs的阻力模式.
- 在这个人群中识别与MDRO殖民相关的风险因素.
主要方法:
- 在5个月的时间内 (2021年4月至8月) 从71名同意透析的患者那里收集了直肠和鼻腔拭子.
- 用选择性染色基质培养样本以确定特定的MDROs.
- 人口,临床和实验室数据被收集和分析.
主要成果:
- 从23.9% (17/71) 的参与者中分离出MDROs.
- 发现了扩展光谱β-乳糖酶生成的肠道细菌 (21.1%) 和耐卡巴胺的肠道细菌 (4.2%).
- 克莱布西拉肺炎是最常见的MDRO (65.2%). 显著的危险因素包括先前住院治疗,使用质子抑制剂和最近接触抗生素.
结论:
- 在被研究的透析患者群体中观察到MDRO携带率很高.
- 现有的感染预防和控制策略需要修订和加强,以减轻MDRO传播.
- 这项研究是撒哈拉以南非洲首次报告在透析患者中显著的MDRO殖民.
相关概念视频
Dialysis
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Dialysis
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
Hemodialysis II: Procedure and Complications
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...


