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Updated: Jun 17, 2025

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

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在高胆固醇贫血患者中报告的LDLR误解变异的细胞和功能评估表明它们对贩运和LDL内部化的低形态影响

Aseel A Jawabri1, Anne John1, Mohammad A Ghattas2

  • 1Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Abu Dhabi, United Arab Emirates.

Frontiers in cell and developmental biology
|August 8, 2024
PubMed
概括

家族性高胆固醇血症 (FH) 通常是由低密度脂蛋白受体 (LDLR) 突变引起的. 这项研究分析了LDLR变体,发现许多影响LDL内部化,有助于FH变异性,并建议治疗点.

关键词:
与ER相关的蛋白质降解 (ERAD)压力ERER压力ERER压力家庭性高胆固醇血症 (FH)低密度脂蛋白 (LDL) 是一种低密度脂蛋白.低密度脂蛋白受体 (LDLR) 是一种低密度脂蛋白受体.蛋白质质量控制 蛋白质质量控制受体介导的内细胞结合症受体介导的内细胞结合症

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