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Updated: Jun 17, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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由于TDP-43核功能的丧失而导致的异常拼接事件:病理生理学和前景

Yuka Koike1,2

  • 1Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan.

JMA journal
|August 8, 2024
PubMed
概括

在肌缩侧硬化症 (ALS) 和前性痴呆症 (FTD) 中,TDP-43蛋白功能障碍会损害RNA剪接. 像STMN2和UNC13A这样的基因中的异常拼接事件有可能成为疾病生物标志物.

关键词:
在ALS/FTD中,一个神秘的外型子.功能丧失 功能丧失在TDP-43中使用.TDP-43自我调节机制 自主调节机制

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