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关于一种新的心血管风险预测得分在狼性炎中的建议

Adél Molnár¹, Márk Juha¹, Klaudia Bulajcsík¹

¹Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.

Frontiers in immunology

|August 8, 2024

概括

系统性红斑狼患者面临高心血管风险. 使用年龄,中性粒细胞计数和透气血压的新CANDE评分可以预测狼性炎的主要不良心血管事件 (MACE).

科学领域:

类风湿病学类风湿病学
心脏病学心脏病学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

系统性红斑狼 (SLE) 患者患心血管疾病 (CVD) 的发病率较高,导致发病率和死亡率增加.
狼性炎是SLE的严重表现,进一步增加了心血管风险.

研究的目的:

评估狼性炎患者发生重大心血管不良事件 (MACE) 的发生情况.
在这个人群中确定MACE的预测因子.
开发心血管风险的预测模型.

主要方法:

在2005年至2020年期间接受脏活检的91名狼性炎患者的回顾性分析.
统计分析以确定临床变量和MACE之间的相关性.
心血管风险的发展基于年龄,中性粒细胞数量和透支血压估计 (CANDE) 评分.

主要成果:

15.38%的患者至少经历过一次MACE;两名患者死于心血管疾病.
增加的年龄,更高的中性粒细胞数量和在活检时更低的透静血压与MACE相关.
年龄,中性粒细胞数量和透气血压被确定为MACE的独立预测因素.

结论:

年龄,中性粒细胞数量和透气血压是狼性炎中MACE的重要危险因素.
该CANDE评分提供了一个简单,具有成本效益的工具来估计这些患者的心血管风险.
强调需要对SLE和心血管风险因素进行综合管理.

关键词:

心血管疾病的风险.脏活组织检查狼性炎是一种神经炎症.主要的心血管不良事件.预测工具是一个预测工具.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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