通过网络药理学探索申伊申混合物中核心成分对高血压的治疗效果
Hai-Yan Wang1, Mo-Li Zhu2, Ya-Wei Hou2
1The Second Affiliated Hospital of Shandong University Jinan 250000, Shandong, China.
American journal of translational research
|August 8, 2024
概括
申益申混合物 (XYM) 通过向多个组件和途径,有效治疗高血压. 这种传统中医药制剂的疗效与瓦尔沙坦相当,是有前途的治疗选择.
科学领域:
- 药理学 药理学是指药理学的学科.
- 系统生物学 系统生物学
- 传统中国医药 传统中国医药
背景情况:
- 高血压是全球主要的健康问题,需要新的治疗策略.
- 传统中医 (TCM) 提供复杂的,多组分的治疗方法,有可能治疗高血压.
- 了解TCM配方的分子机制,如Xuanshen Yishen混合物 (XYM),对于它们的临床应用至关重要.
研究的目的:
- 阐明申益申混合物 (XYM) 在治疗高血压中的作用机制.
- 确定XYM的关键活性成分和分子标.
- 评估XYM在患有基本高血压的患者的临床疗效和安全性.
主要方法:
- 传统中医系统药理学数据库用于组件和目标识别.
- 生物信息学分析包括网络构建 (PPI,药物成分目标) 和丰富分析 (GO,KEGG).
- 对60名基本高血压患者的回顾性临床数据分析,将XYM与对照组进行比较.
主要成果:
- 从Uncaria,Radix Scrophulariae和Epimedium中确定了60个活性成分和98个目标.
- 关键的活性成分 (例如,奎尔丁,凯姆菲罗尔) 和关键的目标 (例如,PTGS2,DPP4) 被精确地确定.
- 突出了重要的途径 (例如IL-17,TNF信号传递),XYM显示了与瓦尔萨坦相比的临床疗效和安全性.
结论:
- 在XYM中,Uncaria,Radix Scrophulariae和Epimedium通过多组件,多目标和多途径机制减轻高血压.
- DPP4,IL-17和TNF-α被确定为高血压中TCM的潜在治疗点.
- 这项研究为XYM在高血压管理中的使用提供了机制基础,并要求进一步调查.
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