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在非小细胞肺癌组织,邻近组织中的RSK4蛋白的表达及其与临床病理特征的相关性

Ru Lou¹, Huawei Shao², Pengcheng Wu²

¹Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310000, Zhejiang, China.

American journal of translational research

|August 8, 2024

概括

核糖体S6激酶4 (RSK4) 蛋白在非小细胞肺癌 (NSCLC) 组织中表达较低. 较低的RSK4表达与晚期NSCLC阶段和更差的预后相关,表明瘤抑制作用.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

非小细胞肺癌 (NSCLC) 仍然是全球癌症相关死亡的主要原因.
了解NSCLC进展背后的分子机制对于开发有效的治疗策略至关重要.
核糖体S6激酶4 (RSK4) 是一种参与各种细胞过程的激酶,但其在NSCLC中的作用尚不清楚.

研究的目的:

与相邻的非瘤组织相比,研究NSCLC组织中RSK4蛋白的表达水平.
确定RSK4蛋白表达与NSCLC患者临床病理特征之间的相关性.
评估RSK4表达在NSCLC中的预后意义.

主要方法:

免疫组织化学染色被用来评估RSK4蛋白表达在100个NSCLC组织样本和相邻的非瘤组织.
收集和分析了临床病理学数据,包括瘤分化,淋巴结转移和TNM阶段.
进行了统计分析,包括考克斯回归和斯皮尔曼相关性,以评估RSK4表达和临床参数之间的关联,以及患者的预后.

主要成果:

与相邻的非瘤组织相比,RSK4蛋白表达在NSCLC组织中明显较低 (35.00%) (69.00%) (P < 0.05).
减少RSK4表达与瘤差异化,晚期TNM阶段和淋巴结转移显著相关 (所有P<0.05).
呈阳性RSK4表达的患者的生存率 (74.29%) 与呈阴性表达的患者相比 (53.85%) (P < 0.05) 高.

结论:

在NSCLC中,RSK4蛋白表达显著下调.
减少RSK4表达与积极的临床病理特征有关,并作为NSCLC潜在的负预后标志物.
RSK4可能在NSCLC中起到瘤抑制作用,突出显示其作为治疗点的潜力.

关键词:

这是一种RSK4蛋白质.临床病理学临床病理学相关性相关性相关性表达方式表达方式表达方式表达非小细胞肺癌的肺癌.预后预后预后

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