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相关概念视频

Action Potentials01:41

Action Potentials

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Overview
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Action Potential01:14

Action Potential

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Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
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Neurons: The Axon01:21

Neurons: The Axon

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Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment....
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Nervous Tissue: Myelin01:25

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The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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Action Potential01:14

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Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
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Arboviral Encephalitis01:25

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Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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轴突多神经病变中的单个简单问题

Vinaya Bhandari1, Alon Abraham2, Leif E Lovblom3

  • 1Ellen & Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Muscle & nerve
|August 8, 2024
PubMed
概括

单一简单问题 (SSQ) 有效地评估轴突多神经病变 (PNP),包括糖尿病神经病变. 虽然可行和有效,但需要进一步的研究来进行全面的PNP评估.

关键词:
轴突性多神经病变是一种轴突性多神经病变.功能和残疾尺度.神经病性疼痛是一种神经性疼痛.一个简单的问题 (SSQ)这是一个弱点,一个弱点.

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科学领域:

  • 神经学 神经学
  • 临床评估 临床评估

背景情况:

  • 单一简单问题 (SSQ) 是一个验证的工具,用于评估严重肌痛和神经病变.
  • 轴突多神经病变 (PNP),如糖尿病神经病变,需要有效的评估工具.

研究的目的:

  • 探索SSQ在评估轴突PNP患者中的实用性.
  • 评估SSQ对疾病规模变化的反应能力.

主要方法:

  • 对150名轴突PNP患者的回顾性图表审查.
  • 使用临床和电生理学评估以及已建立的残疾等级 (MRC总分,mTCNS,ONSLS,RODS).

主要成果:

  • SSQ与RODS (r=0.59) 和mTCNS症状得分 (r=-0.43) 显示出中等相关性.
  • 在mTCNS症状得分的变化显示统计学意义纵向.
  • 患有疼痛的患者的SSQ得分较低,并且与电生理学参数无关.

结论:

  • SSQ是一个可行的和有效的尺度,用于评估和监测长度依赖的轴突PNPs.
  • 由于SSQ与其他尺度的联系有限,因此在PNP评估中需要进行补充评估.