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Updated: Jun 17, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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独特的基于氨基酸的PROTACs向瘤性激酶,以降解非小细胞肺癌 (NSCLC) 的降解

Jianchao Zhang1, Xiao Chen1, Congli Chen2

  • 1Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.

Journal of medicinal chemistry
|August 8, 2024
PubMed
概括

新的基于氨基酸的PROTACs (AATacs) 提供了一种多功能策略,用于降解非小细胞肺癌 (NSCLC) 中引起疾病的蛋白质,如EML4-ALK和突变EGFR. 这些小分子微调蛋白质的减少,抑制癌细胞的生长.

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