颗粒物暴露和早产在异常预孕的妇女中的相关性 甲状腺激素水平:大型队列研究
Ting Xu1, Haobo Ni1, Xiaoyan Cai1
1Department of Preventive Medicine, Shantou University Medical Colleage, Shantou, China.
JMIR public health and surveillance
|August 8, 2024
概括
暴露于细颗粒物 (PM2.5) 增加了早产 (PTB) 的风险,特别是对于有异常甲状腺刺激激素 (TSH) 水平的孕妇. 这种风险在怀孕早期和晚期更为明显.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 内分泌学 在内分泌学.
背景情况:
- 颗粒物 (PM2.5) 暴露是早产 (PTB) 的已知危险因素.
- 甲状腺刺激激素 (TSH) 水平对PM2.5和PTB关系的影响仍然未被探索.
研究的目的:
- 调查是否预设的TSH水平调节了PM2.5暴露和PTB之间的关联.
- 为了确定与TSH水平相关的PTB风险的PM2.5暴露敏感性的特定妊娠窗口.
主要方法:
- 在中国广东省对633516名女性进行了一项大型队列研究.
- 使用反向距离权重估计了PM2.5暴露.
- 考克斯的比例危险和分布式滞后模型被用来分析季度特定的和每周的PM2.5暴露对PTB的影响,考虑到TSH水平.
主要成果:
- 与正常TSH水平 (HR 1.345) 相比,与PM2.5暴露相关的PTB风险显著更高 (HR 1.559) 的女性具有异常的TSH水平.
- 在两个TSH组中,PM2.5暴露与早期和晚期PTB的风险增加有关.
- 对PM2.5暴露的敏感窗口不同:异常TSH的第3至13周和第28至35周,与正常TSH的第1至13周和第21至35周相比.
结论:
- 不正常的TSH水平加剧了与PM2.5暴露相关的PTB风险.
- 在怀孕早期和晚期,PM2.5带来更大的风险,特定窗口受TSH状态的影响.
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