现型年龄与心力衰竭患者死亡风险之间的关联:回顾性队列研究
1Department of Cardiovascular Medicine, Huadu District People's Hospital of Guangzhou, Guangzhou, Guangdong, People's Republic of China.
Clinical cardiology
|August 8, 2024
概括
生物衰老措施,表型年龄 (PhenoAge) 和表型年龄加速 (PhenoAgeAccel),与心力衰竭 (HF) 患者的死亡风险更高有关. 这些标记可以帮助识别有风险的个体,并评估治疗的有效性.
科学领域:
- 老年学是指老年学的学科.
- 心血管医学 心血管医学
- 生物标志物 生物标志物
背景情况:
- 时间学年龄是生物衰老的不足指标.
- 表型年龄 (PhenoAge) 和表型年龄加速 (PhenoAgeAccel) 是生物衰老的新型生物标志物.
- 这些生物标志物已证明在预测一般人口的发病率和死亡率方面具有实用性.
研究的目的:
- 调查PhenoAge,PhenoAgeAccel和心力衰竭 (HF) 患者全因死亡率之间的关联.
- 确定PhenoAge和PhenoAgeAccel是否可以作为HF患者死亡风险的预测工具.
主要方法:
- 一项使用国家健康和营养检查调查 (NHANES) 数据的队列研究.
- 使用加权的单变量和多变量考克斯比例危险模型.
- 为了评估死亡风险,计算了危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 增加的PhenOAge与HF患者全因死亡风险更高显著相关 (例如,增加PhenOAge10年与41%的风险增加相关).
- 与PhenoAgeAccel < 0 (HR=1.91) 相比,PhenoAgeAccel ≥ 0与所有原因死亡的风险大大增加有关.
- 亚组分析证实了各种患者亚组中的这些关联.
结论:
- 老年PhenOAge是心力衰竭患者全因死亡率增加的重要预测因素.
- PhenoAge和PhenoAgeAccel是识别高风险HF患者的有价值和可访问的工具.
- 这些生物标志物可以帮助评估旨在改善高频结果的干预措施的有效性.
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