术后荷尔蒙疗法后的无复发性存活率,用于甲状腺性肺胸部
Ji Hoon Kim1, Won-Gi Woo1, Yong-Ho Jung1
1Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Journal of chest surgery
|August 8, 2024
概括
手术后的激素治疗并没有显著降低门性肺胸部 (CP) 患者的复发. 隔膜切除是发现防止手术后CP复发的唯一重要因素.
科学领域:
- 胸部外科手术 胸部外科手术
- 妇科外科手术 妇科外科
- 肺部病理学 肺部病理学
背景情况:
- 甲状腺性肺胸 (CP) 是一种与子宫内膜异位症相关的罕见疾病,主要影响生殖年龄的女性.
- 手术后的荷尔蒙疗法通常被认为是在CP的外科干预后进行的.
- 这项研究调查了CP手术后激素治疗的临床影响.
研究的目的:
- 评估手术后激素治疗在预防甲状腺性肺胸部 (CP) 复发方面的疗效.
- 为了确定与术后CP复发相关的风险因素.
主要方法:
- 在2009年至2023年期间,对41名为CP (切除,隔膜切除或胸膜覆盖) 进行手术的患者进行了回顾性分析.
- 卡普兰-梅尔日志等级测试用于无复发生存分析.
- 考克斯比例危险分析,以确定复发风险因素.
主要成果:
- 27名患者接受了激素治疗,8名患者在中位数为1年的随访期间出现了复发.
- 接受激素治疗的患者出现了较低复发的趋势,但这在统计学上并不显著 (p>0.05),可能是由于样本规模较小.
- 隔膜切除被确定为预防术后CP复发的重要保护因素 (HR,0.16;95% CI,0.03-0.77;p=0.022).
- 据报道,激素治疗的副作用包括抑郁症,过度出汗和头痛.
结论:
- 术后的激素治疗与手术相结合并没有显著降低CP复发率.
- 隔膜切除成为预防CP复发的唯一统计学显著因素.
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