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自由甲状腺素与中期和高风险差异化甲状腺癌无进展生存的关联

Raisa Ghosh¹, Sungyoung Auh¹, Sriram Gubbi¹

¹National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20814, USA.

The Journal of clinical endocrinology and metabolism

|August 8, 2024

概括

增加的自由甲状腺素 (FT4) 水平不会影响差异化甲状腺癌患者的无进展生存期 (PFS). 这一发现与临床前数据形成鲜明对比,这些数据表明T4可能刺激癌症生长.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
甲状腺癌研究研究

背景情况:

超生理性甲状腺素 (T4) 剂量是中等和高风险差异化甲状腺癌 (IR/HR-DTC) 的标准,以抑制甲状腺刺激激素 (TSH).
临床前研究表明T4可能会促进癌症生长,但临床证据缺乏.

研究的目的:

在IR/HR-DTC患者中研究自由甲状腺素 (FT4) 水平和无进展生存期 (PFS) 之间的关联.

主要方法:

一个纵向的队列研究IR/HR-DTC患者均治疗甲状腺切除术,放射性和TSH抑制.
使用卡普兰-梅尔曲线和考克斯比例危险模型来评估FT4和PFS之间的关联.

主要成果:

升高的FT4水平 (在29.3%的患者中观察到) 与更糟糕的PFS无关 (HR,0.9;P = .69).
与较短的PFS相关的因素包括年龄,瘤大小和淋巴结,骨和大脑的转移.

结论:

临床发现表明,高FT4水平不会对IR/HR-DTC患者的PFS产生负面影响.
这与一些临床前数据相矛盾,这些数据表明T4对癌症具有潜在的增长刺激作用.

关键词:

没有进展的生存率.甲状腺癌是一种癌症.甲状腺增生蛋白抑制抑制甲状腺素甲状腺素

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