乳头甲状腺癌的患病率在同步甲状腺结节的Graves疾病中显著更高
Mehmet Kefeli1, Hasan Gucer2, Elif Tutku Durmuş3
1Department of Pathology, Ondokuz Mayis University, SAMSUN, TÜRKİYE.
Turk patoloji dergisi
|August 8, 2024
概括
患有结节性甲状腺组织的格雷夫斯病 (GD) 患者患有乳头甲状腺癌 (PTC) 的患病率更高. 在GD患者中发现的大多数PTC是低风险的亚厘米瘤.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 自免疫相关的组织损伤与癌症的发展有关.
- 格雷夫斯病 (GD) 患者可能患有差异化甲状腺癌的风险增加.
- 需要进一步的研究来了解GD患者的乳头甲状腺癌 (PTC).
研究的目的:
- 调查来自GD患者的甲状腺切除样本中的PTC和同步甲状腺结节的患病率.
- 为了比较结节性GD (N-GD) 和简单GD (S-GD) 患者之间的PTC患病率和特征.
- 分析与GD中PTC相关的基因病理相关性和人口特征.
主要方法:
- 两家三级医疗中心对237名手术治疗的GD患者的病理记录进行了回顾性审查.
- 根据超声波,将患者分为N-GD (有同步结节) 和S-GD (没有同步结节) 的分类.
- 在N-GD和S-GD组之间比较PTC患病率,病原体特征和人口统计数据.
主要成果:
- 总体而言,PTC频率为36.3%.
- 与S-GD (21.7%) 相比,N-GD (48.1%) 的PTC患病率显著更高.
- 在这两组中,大多数PTC都是亚厘米瘤.
结论:
- 在GD患者中PTC的患病率受到底层结节性甲状腺组织的存在的影响.
- 与S-GD患者相比,N-GD患者的PTC发病率较高.
- 与GD相关的PTC主要是低风险的亚厘米病变.
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