怀孕期间使用阿诺洛是否会对妊娠年龄的新生儿造成小? 一个元分析
Shauna Bratton1, Megan K Taylor1, Priscilla Cortez1
1College of Medicine, University of Arizona, Tucson, AZ, USA.
Journal of perinatal medicine
|August 8, 2024
概括
怀孕期间使用阿提诺洛尔可能会增加新生儿对于妊娠年龄来说小的风险,与其他β阻塞剂相比. 这一元分析表明,在给孕妇处方阿提诺洛尔时,应谨慎.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 新生儿科学 新生儿科学
背景情况:
- 贝塔抑制剂阿提诺洛尔 (Atenolol) 经常被处方给非孕妇.
- 由于潜在的胎儿生长限制,人们对阿诺洛尔在怀孕期间的安全性存在担忧.
- 临床犹围绕着在孕妇人群中服用阿提诺洛的处方.
研究的目的:
- 为了评估阿提诺洛尔使用与妊娠年龄小 (SGA) 新生儿发病率之间的关联.
- 为了比较与阿提诺洛尔相关的SGA风险与怀孕期间其他β阻塞剂的风险.
- 综合现有的关于阿诺洛和胎儿生长结果的文献.
主要方法:
- 采用了元分析方法来综合相关研究的数据.
- 创建了森林地块,以可视化SGA的风险比率 (RR).
- 统计异质性使用I平方 (I2) 统计量化.
主要成果:
- 在分析中包括了两项研究.
- 与阿提诺洛尔相关的SGA的整体风险比 (RR) 为1.94 (95% CI为1.60;2.35).
- 没有观察到统计异质性 (I2 = 0%).
结论:
- 怀孕期间使用阿提诺洛尔与分娩的风险增加有关,这些新生儿的妊娠年龄较小.
- 与其他常用的β阻塞剂相比,这种风险较高,包括labetalol,propranolol,bisoprolol和metoprolol.
- 研究结果表明,需要仔细考虑在怀孕期间使用替代β抑制剂.
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