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监测ER-Phagy的方法

Marisa Di Monaco1, Marian Peteri1, Jin Rui Liang2

  • 1MRC Protein Phosphorylation & Ubiquitylation Unit, University of Dundee, Dundee, UK.

Methods in molecular biology (Clifton, N.J.)
|August 8, 2024
PubMed
概括

细胞内网络特异性自 (ER-phagy) 消除受损的ER部分,以保持细胞健康. 本研究详细介绍了研究ER-phagy的方法,这对于细胞适应和疾病预防至关重要.

关键词:
自自是一种自的过程.这是ER-phagy.细胞内膜网膜是什么 细胞内膜网膜传真 (FACS) 是一个事实.光记者 光记者免疫光效应 免疫光效应选择性自可以选择性自.西方涂抹是指西方涂抹.

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After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...