针对性免疫疗法治疗中期和晚期肝癌患者的症状集群和网络分析
Mei Chen1, Shan Li2, Guangzhi Jin3
1Wuxi Medical College, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, 214122, China.
概括
在接受向免疫治疗的肝癌患者中,确定疼痛和恶心等核心症状是关键. 对这些和桥梁症状进行干预可以改善整体症状管理和患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 症状科学 症状科学
- 免疫治疗是一种免疫疗法.
背景情况:
- 中期和晚期肝癌患者在向免疫治疗期间经常经历多种相互关联的症状.
- 了解这些症状集群对于有效管理至关重要.
研究的目的:
- 在接受向免疫治疗的肝癌患者中识别症状集群.
- 确定核心和桥梁症状,以精确的症状管理.
主要方法:
- 在中国上海进行方便采样的横截面调查 (2023年5月至2024年1月).
- 使用纪念症状评估尺度来评估症状严重程度.
- 采用网络分析来绘制症状的相互关系,并确定核心/桥梁症状.
主要成果:
- 确定了五个症状集群:口腔,胃肠道,疲劳相关,身体形象和疼痛睡眠.
- 核心症状:疼痛",我看起来不像我自己",恶心. 桥梁症状:疼痛,,胀气. 这种情况可能会导致:
- 最强的症状连接:恶心-吐,味道变化-口腔干燥,减肥-"我看起来不像我自己".
结论:
- 同时,相互关联的症状在接受向免疫治疗的肝癌患者中很常见.
- 针对核心和桥梁症状可以个性化管理,提高疗效,提高生活质量.
- 研究结果为改善患者治疗结果提供了临床和研究见解.
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:27Tumor Immunotherapy
497
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
497
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K