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Updated: Jun 17, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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在多发性硬化症中的微细胞特异性替代拼接变化

Caiyun Qi1, Honglei Ren2, Yong Fan1

  • 1Department of Obstetrics and Gynecology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Aging
|August 8, 2024
PubMed
概括

这项研究揭示了多发性硬化症 (MS) 患者微质中的细胞类型特定的替代拼接 (AS) 变化. 这些发现突出了MS白质病理学的新型分子机制.

关键词:
替代性拼接是一种替代性的拼接.多发性硬化症多发性硬化症相互排斥的前代子.保持了内在的内.跳过一个exon.

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RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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