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揭开关节炎的分歧:探索治疗反应和治疗后期发病与早期发病的类风湿性关节炎的影响

Nariaki Hao¹, Hajime Ishikawa¹, Asami Abe¹

¹Department of Rheumatology, Niigata Rheumatic Center, Niigata, Japan.

Modern rheumatology

|August 8, 2024

概括

骨关节炎显著影响老年人类类类风湿性关节炎治疗结果. 与没有骨关节炎的患者相比,患有骨关节炎的晚期类风湿性关节炎患者的疾病控制和日常功能表现更差.

科学领域:

类风湿病学类风湿病学
老年医学老年医学
免疫学免疫学免疫学

背景情况:

类风湿性关节炎 (RA) 管理的目标是使用治疗到目标策略的缓解.
诸如骨关节炎 (OA) 这样的并发症可能会影响RA治疗反应.
区分年轻发 RA (YORA) 和晚期发 RA (LORA) 对于了解疾病轨迹至关重要.

研究的目的:

为了比较骨关节炎 (OA) 对类风湿性关节炎 (RA) 初始治疗反应的影响.
评估晚期发 RA (LORA) 和年轻发 RA (YORA) 患者与没有OA之间的治疗结果的差异.

主要方法:

对RA患者的回顾性研究 (2021年1月 - 2022年7月).
如果Kellgren-Lawrence等级≥3在膝盖或手部,患者被归类为OA (+);否则OA (-).
对LORA (n=74) 和YORA (n=59) 队列的诊断和治疗后1年的临床数据进行比较.

主要成果:

在LORA患者中,与OA (-) 相比,OA (+) 患者在1年后表现出较差的疾病活动控制和更大的日常生活残疾.
在OA (+) 和OA (-) YORA患者之间没有观察到日常生活残疾的显著差异.
在LORA组中,OA的患病率较高.

结论:

骨关节炎对晚发性类风湿性关节炎的初始治疗反应产生更大的负面影响,而不是年轻发性类风湿性关节炎.
这些发现强调了在管理LORA患者时考虑骨关节炎并发症的重要性.
治疗目标策略可能需要在LORA患者同时患有骨关节炎时进行调整.

关键词:

骨关节炎是一种骨关节炎.功能性缓解功能性缓解晚期发作的类风湿性关节炎类风湿性关节炎类风湿性关节炎年轻发病的类风湿性关节炎.

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