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Updated: Jun 17, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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在Brca1相关的乳腺瘤发生过程中,R循环功能

Huai-Chin Chiang1, Leilei Qi2, Payal Mitra1

  • 1Department of Biochemistry and Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037.

Proceedings of the National Academy of Sciences of the United States of America
|August 8, 2024
PubMed
概括

R环,DNA-RNA结构,有助于基因组不稳定性和与BRCA1相关的乳腺癌. 移除BRCA1缺乏细胞中的R环改变了瘤亚型,这表明R环会影响原始癌细胞.

关键词:
这就是BRCA1的原因.在R-Loop中使用.鼠标遗传学 鼠标遗传学瘤发生的起源

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