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Updated: Jun 17, 2025

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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胰岛素晶体药物之间的高阶结构差异通过2D异核核NMR揭示

Songlin Wang1, Chad M Rienstra1,2,3, Kang Chen4

  • 1National Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison, Madison, WI-53706, United States.

ChemMedChem
|August 8, 2024
PubMed
概括

使用异质核相关性 (HETCOR) 的固态核磁共振 (SSNMR) 现在可以分析晶体药物中的蛋白质高阶结构 (HOS). 这种方法可以区分胰岛素配方,有助于生物类似药物的开发.

关键词:
药品质量评估 药品质量评估 药品质量评估更高阶结构的特征描述.胰岛素 NPH 晶体蛋白质结构 蛋白质结构固态NMR是一种固态NMR.

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