与坦桑尼亚东北部多发性骨髓瘤患者的生存相关的因素
Faryal M Raza1, Elifuraha W Mkwizu1,2,3, Steven A Leak2,4
1Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
JCO global oncology
|August 8, 2024
概括
坦桑尼亚多发性骨髓瘤 (MM) 诊断显示,老年患者有骨疼痛,贫血和晚期. 生存是有限的,感染是死亡的主要原因,强调了早期检测的必要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 多发性骨髓瘤 (MM) 是一种具有重大全球健康影响的血液性恶性瘤.
- 由于诊断和结果的潜在差异,了解撒哈拉以南非洲的MM特征至关重要.
研究的目的:
- 在坦桑尼亚诊断多发性骨髓瘤 (MM) 的临床,实验室和成像发现的特征.
- 概述治疗方法和五年生存率.
- 确定影响坦桑尼亚MM患者生存的因素.
主要方法:
- 在2017年1月至2022年6月期间诊断出76名MM患者的回顾性队列研究.
- 数据收集包括人口统计,临床资料和生存结果.
- 卡普兰-梅尔总生存时间 (OS) 分析,使用单变量和多变量考克斯回归.
主要成果:
- 骨头疼痛 (76.3%) 和晚期 (82.7% 阶段III) 是常见的;患者通常在50岁以上.
- 贫血 (51.3%) 和高血症 (23.9%) 是常见的实验室发现.
- 平均生存期为18.0个月;贫血,功能衰竭和骨参与预测了更短的生存期. 感染是导致死亡的主要原因.
结论:
- 这项研究提供了关于撒哈拉以南非洲MM的见解,并指出了诊断挑战及其对生存的影响.
- 骨头疼痛是一个显著的呈现症状,它的存在会影响结果.
- 对于早期诊断,改进诊断和量身定制的干预措施至关重要,以改善该地区MM患者的治疗结果.
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