在胃癌患者中,AWGC-cachexia和GLIM-营养不良之间的比较
Su-Lin Wang1, Feng-Min Zhang2, Chen-Bin Chen3
1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
概括
亚洲卡切西亚工作组 (AWGC) 和全球营养不良领导倡议 (GLIM) 标准是评估胃癌患者的独特工具. 缓解症和营养不良都独立地预测了生存率,同时诊断恶化了结果.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 亚洲卡切西亚工作组 (AWGC) 标准和全球营养不良领导倡议 (GLIM) 标准共有诊断要素.
- 胃癌患者经常出现缓冲症和/或营养不良,影响预后.
研究的目的:
- 在胃癌患者中比较AWGC定义的缓解症和GLIM定义的营养不良的诊断效用.
- 为了确定一个诊断是否在另一个诊断存在时仍然是一个预后因素.
主要方法:
- 来自1420名经过激进胃切除术的胃腺癌患者的前性数据收集 (2013-2019).
- 应用AWGC和GLIM标准,分别用于卡赫克西亚和营养不良的诊断.
- 针对术后并发症和整体存活期的单变量和多变量后勤和考克斯回归分析.
主要成果:
- 12.3%的人单独患有AWGC-缓冲症,6.0%的人单独患有GLIM营养不良,22.8%的人患有两者.
- 无论是AWGC-cachexia还是GLIM-营养不良都是并发症和整体存活时间的独立风险因素.
- 每一种情况仍然是生存的重要预测因素,即使在其他诊断的存在下也是如此.
结论:
- AWGC-cachexia和GLIM-营养不良是一种非冗余的诊断工具.
- 这些标准有效地确定了胃癌患者手术前营养评估中的死亡风险.
相关概念视频
01:20Comparing the Survival Analysis of Two or More Groups
166
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
166
01:21Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334