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系统性炎症期间下丘脑中血清素释放的性变异:内甲蛋白-1的作用
Regina Azevedo Costa1, Jefferson Angulski Amatnecks1, Gisele de Oliveira Guaita1
1Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Brazil.
Journal of neuroimmunology
|August 8, 2024
概括
系统性炎症在雄性和雌性大鼠中不同影响下丘脑中的血清激素水平. 内甲素-1 (ET-1) 在调解这些性别特异性变化以及由此产生的发烧和运动减少方面发挥着关键作用.
科学领域:
- 神经内分泌学神经内分泌学
- 神经免疫学 神经免疫学
- 行为神经科学 行为神经科学
背景情况:
- 下丘脑调节关键的生理过程,包括体温和行为.
- 脑下垂体中的血清能 (5-HT) 路径显示出性别特异性的调节.
- 系统性炎症可以改变大脑中的神经化学信号.
研究的目的:
- 在全身炎症期间研究内甲素-1 (ET-1) 在性别特异性下丘脑血清激素 (5-HT) 变化中的作用.
- 检查ET-1在由脂多糖 (LPS) 诱导的发烧和低血压运动中的作用.
主要方法:
- 向雄性和雌性大鼠注射脂聚糖 (LPS),以诱导全身炎症.
- 测量了血清素 (5-HT) 和其代谢物5-基因醇酸 (5-HIAA) 的下丘脑水平.
- 使用的脑内静脉 (ICV) 使用ET-1和内甲素-B受体对抗剂 (BQ788) 的治疗.
主要成果:
- 在两种性别中,LPS诱导发烧和下,但在下丘脑5-HT和5-HIAA水平上有差异性变化.
- 在男性中,LPS降低了下丘脑中的5-HT和5-HIAA,而在女性中增加了它们.
- BQ788的使用阻断了LPS诱导的效应,ET-1的使用模仿了LPS对发烧,下垂运动和下丘脑5-HT的影响.
- 在雄性和雌性大鼠中,ET-1的使用降低了下丘脑中的5-HT和5-HIAA水平.
结论:
- 系统性炎症在下丘脑5-HT释放过程中引发了显著的性变异.
- 内末林-1 (ET-1) 是LPS诱导的发烧,低血压和改变的下丘脑5-HT水平的关键媒介,在雄性和雌性大鼠中.
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