在母猪怀孕和哺乳期间的唾液中皮质醇,皮质素和11β-基类固醇脱酶II型活性的变化
M Botía1, D Escribano2, F Tecles1
1Interdisciplinary Laboratory of Clinical Analysis, Interlab-UMU, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, 30100 Murcia, Spain.
Domestic animal endocrinology
|August 8, 2024
概括
这项研究调查了猪的压力,该研究发现11β-基类固醇脱酶II型 (11β-HSDII型) 酶活性和皮质素水平在产后下降,而皮质醇增加,这表明不同生殖阶段的生理反应不同.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物生理学 动物生理学
- 内分泌学 在内分泌学.
背景情况:
- 通过皮质醇和皮质素测量的11β-基固醇脱酶II型 (11β-HSDII型) 酶活性是猪的关键压力标志物.
- 在关键的生殖阶段 (如怀孕,分娩和哺乳期) 了解压力生物标志物对于动物福利至关重要.
研究的目的:
- 为了研究11β-HSDII类型的活性和唾液皮质醇/皮质素度在整个孕期,生育期和哺乳期猪.
- 将这些荷尔蒙标记与其他已知的压力生物标记者进行比较,包括染色素A (CgA),S100A12和α-amylase.
主要方法:
- 从猪身上采集了唾液样本,这些样本是在猪怀孕,生育和哺乳期间采集的.
- 通过测量皮质醇和皮质素度来估计II型11β-HSD的酶活性.
- 为了进行比较分析,还量化了CgA,S100A12和α-amylase的水平.
主要成果:
- 唾液皮质子度和11β-HSDII型活性在产后显著下降.
- 皮质醇度在分娩后显著增加.
- 没有发现11β-HSDII类型活性与其他测量的压力生物标志物 (CgA,S100A12,α-amylase) 之间的显著相关性.
结论:
- 11β-HSD II型活性和皮质醇/皮质素水平在猪怀孕和哺乳期间表现出不同的调节模式.
- 这些发现强调了在解释唾液11β-HSDII型活性和激素度作为压力指标时考虑特定生理阶段的重要性.
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