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在使用捐赠卵子的高级孕妇年龄 (≥45岁) 的妇女中,试管婴儿和产科结果

Ta-Sheng Chen¹, Pao-Lin Kuo², Tsung Yu³

¹Department of Gynaecology and Gynaecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Reproductive biomedicine online

|August 8, 2024

概括

使用捐赠卵细胞进行体外受精 (IVF) 为母亲年龄非常晚的妇女 (VAMA) 提供了可行的怀孕选择,无论年龄如何,均的活产率. 推选择性单胚移植 (SET),以尽量减少双胞胎怀孕的风险.

科学领域:

生殖医学生殖医学
在体外受精 (IVF)
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

非常高级的孕产妇年龄 (VAMA),定义为45岁及以上,在实现成功的怀孕结果方面提出了独特的挑战.
像IVF这样的辅助生殖技术与捐赠卵细胞越来越多地被VAMA的妇女使用.

研究的目的:

调查VAMA对使用捐赠卵子进行体外受精的妇女产科和周产期结局的影响.
评估母亲年龄对累积活产率 (CLBR) 和其他关键怀孕和分娩参数的影响.

主要方法:

追溯性队列研究分析了台湾 (2007-2016) 全国IVF注册数据.
包括1226个胚胎移植周期,来自745名45岁及以上的女性,使用了捐赠卵子.
评估的CLBR,临床怀孕,流产,活产,双胞胎怀孕率和围产期结果.

主要成果:

在整个研究期间,观察到约40%的稳定活产率.
在年龄组 (45-46岁与50岁以上) 之间没有发现CLBR,次要结果或围产期结果的统计学上显著差异.
单个胚胎移植 (SET) 与双胞胎怀孕的风险降低有关,而不会影响活产率.

结论:

用捐赠卵子进行试管婴儿对VAMA的女性来说是一个成功的选择,在这个群体内的不同年龄层中显示出一致的活产率.
选择性单胚移植 (SET) 对于减轻与双胞胎怀孕相关的风险至关重要.
进一步的研究应该探索在接受试管婴儿的VAMA患者中的其他因素,如父亲的年龄和胚胎质量.

关键词:

晚期的母亲年龄晚期的母亲年龄在这个过程中,IVF IVF.多重怀孕是一个多重怀孕.卵细胞捐赠的方法单个胚胎转移是一个胚胎转移.

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