在良性和恶性甲状腺疾病中完整血清比率的临床价值
Chen Jiang1, Yi Wu2, Jianhui Huang3
1Department of Blood Transfusion, Affiliated Hospital of Nantong University, Nantong, China.
Cancer epidemiology
|August 8, 2024
概括
血液常规衍生生物标志物如血小板与淋巴细胞比率 (PLR),中性粒细胞与淋巴细胞比率 (NLR) 和血小板大细胞率 (P-LCR) 可以帮助区分良性与恶性甲状腺疾病. 这些标记物还有助于区分各种良性甲状腺疾病.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 甲状腺疾病包括一系列良性和恶性疾病.
- 准确的区分对于适当的患者管理至关重要.
- 需要新的生物标志物来提高诊断准确度.
研究的目的:
- 评估血液常规衍生物生物标志物和甲状腺功能测试在区分甲状腺疾病的临床实用性.
- 评估这些生物标志物在良性和恶性甲状腺疾病之间区分的能力.
- 为了比较这些标记物在各种良性甲状腺疾病的诊断价值.
主要方法:
- 在良性和恶性甲状腺疾病之间比较中性细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),淋巴细胞与单细胞的比率 (LMR) 和血小板大细胞率 (P-LCR).
- 在各种良性甲状腺疾病中分析这些指数的差异.
- 应用单变量回归和接收器操作特征 (ROC) 曲线分析以确定临床价值和诊断准确性.
主要成果:
- 在良性和恶性甲状腺疾病之间观察到PLR,NLR和P-LCR的统计学上显著差异 (P <0.05).
- 统变逻辑回归表明,增加的PLR和NLR与甲状腺恶性瘤风险降低有关,而增加的P-LCR与风险增加相关.
- 在区分良性与恶性甲状腺疾病方面,LMR没有显示出统计学上显著的差异.
结论:
- PLR,NLR和P-LCR是区分良性和恶性甲状腺疾病的有价值的生物标志物.
- 这些血液学指数还表明,在区分各种类型的良性甲状腺疾病方面具有实用性.
- 这些发现表明,常规的血液衍生标记可以补充现有的甲状腺疾病诊断方法.
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