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麻醉和手术后海马体代谢的急性变化:对外科手术期间神经认知障碍的影响

Yong Qiu¹, Chunheng Mo², Jiachen Li²

¹Department of Anesthesiology, National Clinical Research Center for Geriatrics and the Research Units of West China (2018RU012), West China Hospital, Sichuan University, Chengdu, China; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

Biochemical and biophysical research communications

|August 8, 2024

概括

麻醉和手术可以通过改变大脑新陈代谢导致认知能力下降. 这项研究确定了海马体中的特定代谢物变化,为外科手术期间神经认知障碍 (PND) 机制提供了见解.

科学领域:

神经科学是一个神经科学.
代谢学代谢学代谢学
麻醉学麻醉学

背景情况:

术后神经认知障碍 (PND),包括术后认知功能障碍 (POCD) 和痴呆症,与痴呆症风险增加有关.
麻醉和手术与PND相关,急性代谢变化可能是潜在的认知障碍.
有限的研究存在于手术期间的海马体代谢变化,在特定的代谢物上有相互矛盾的发现.

研究的目的:

为了研究麻醉和手术后海马体的急性代谢变化.
建立一个小鼠模型来研究麻醉和手术诱导的认知障碍.
为了确定受外科手术压力影响的特定代谢物和代谢途径.

主要方法:

开发了一种使用异氨酸麻醉和单边切除术的小鼠模型.
通过Y迷宫和恐惧调节测试评估认知功能.
使用液态染色体质谱法 (LC-MS) 分析海马体代谢量,以确定差异代谢物.

主要成果:

麻醉和手术诱导了小鼠模型中的认知衰退.
观察到代谢物水平的显著变化:49个上调和122个下调.
受影响的代谢途径包括 purin,glutathione,nicotinate 和 nicotinamide 的代谢,主要的代谢物如NAD已被确定.

结论:

麻醉和手术诱导急性海马体代谢变化.
这些变化涉及脂质,氨基酸,核酸和碳水化合物代谢中的代谢物.
已识别的代谢物可能通过调节神经炎症,氧化应激和血脑屏障透性来影响PND.

关键词:

这是BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB 在海马体内,海马体脂质代谢脂质的代谢代谢学代谢学代谢学 PND PND 这是一个很好的方法.

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