具有pH值和离子响应性的水溶性生物降解聚合物
Xiao Li1, Wei-Zhen Zheng1, Peng-Yuan Xu1
1National Engineering Research Center of Engineering Plastics and Ecological Plastics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Journal of hazardous materials
|August 8, 2024
概括
新的水溶性和可生物降解的聚合物被开发使用聚丁酸-co-甲) 和1-3-异甲-5-硫酸. 这些离子共聚合物表现出针对药物输送应用的调节性降解.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
背景情况:
- 开发水溶性和可生物降解的聚合物对于减少环境影响至关重要.
- 半芳香型共聚合物,如聚乙烯酸-共乙烯甲酸 (PBST),具有可生物降解性.
- 修改现有的可生物降解聚合物可以提高它们在特定应用中的功能.
研究的目的:
- 合成新型水溶性和生物降解性共聚合物.
- 研究离子群对聚合物特性和降解的影响.
- 探索这些材料在可控药物输送系统中的潜力.
主要方法:
- 将PBST与1-3-异甲-5-硫酸盐 (SIPA) 溶解共聚化,以产生PBSTS.
- 水友性,吸水性和反应性 (离子和温度) 的表征.
- 在各种模拟体液中评估pH依赖性降解.
主要成果:
- 合成的聚丁酸-co-butylene terephthalate-co-butylene 5-sodiosulfoisophthalate (PBSTS) 共聚合物是水溶性的,具有离子和温度的反应性.
- 降解速度取决于pH值,在pH值5.5和8.5时加速,在pH值7.2时抑制.
- 在模拟的胃液 (pH1.5) 中发生了显著的降解,在肠道 (pH6.8) 和生理液 (pH7.0) 中降解最小.
结论:
- 新型的离子可生物降解共聚合物表现出独特的pH响应性降解特征.
- 在酸性环境中的选择性降解表明有针对性的药物递送的潜力.
- 这些材料为人体内的局部和受控释放应用提供了一个有前途的平台.
相关概念视频
Types of Step-Growth Polymers: Polyesters
2.2K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
2.2K
Potentiometry: Membrane Electrodes
504
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
504
Ion Exchange
566
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
566
Polyprotic Acids
29.1K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
29.1K


