相关实验视频

Updated: Jun 17, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

标有PPIC标签的CAF:是胃癌新辅助化疗耐药性的关键参与者

Honghao Yin¹, Lili Sun², Yuan Yuan¹

¹Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, China.

Translational oncology

|August 8, 2024

概括

特定的癌症相关纤维细胞 (CAF) 子组,通过PPIC表达确定,与胃癌 (GC) 中的新辅助化疗 (NCT) 耐药性有关. 这一发现为克服GC患者药物耐药性的潜在新目标提供了机会.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
分子医学是分子医学.

背景情况:

胃癌 (GC) 是癌症死亡的主要原因,晚期显示生存率差.
新辅助化疗 (NCT) 对于GC治疗至关重要,但常常因药物耐药性而受到阻碍.
与癌症相关的纤维细胞 (CAFs) 促进了GC药物耐药性,但涉及的特定CAF亚群仍然不清楚.

研究的目的:

确定特定的癌症相关纤维细胞 (CAF) 亚群,这些亚群有助于胃癌 (GC) 中的新辅助化疗 (NCT) 耐药性.
调查PPIC基因及其编码蛋白,环菲林C (CypC) 在GC化学抵抗中的作用.

主要方法:

差异基因表达分析 (GEO2R) 用于比较化学敏感和耐药GC患者.
单细胞RNA测序 (scRNA-seq) 来识别与CAF相关的基因.
免疫组织化学验证GC组织中的关键基因表达 (CypC) 并与治疗反应和临床特征相关联.

主要成果:

在CAF中高度表达的PPIC基因与GC中的NCT抵抗有显著的关联.
环素C (CypC) 表达在抗性GC组织中比敏感组织更高 (69.7%与43.6%相比).
高CAF CypC表达与较大的瘤大小,先进的T和TNM阶段以及血管入侵相关,但不是整体存活率 (OS).

结论:

被标记为PPIC的CAF子组与GC化学抵抗和更差的预后有关.
这些CAF子组可能通过葡萄糖代谢和细胞外矩阵重塑等途径诱导耐药性.
需要进一步的研究来阐明PPIC标记的CAF在GC药物耐药性的精确机制.

关键词:

在 CAF 中,CAF 是 CAF.化学抗药性化学抗药性是一种抗药性.这就是CypCC的意思.胃癌胃癌是指胃癌.免疫微环境是一个微环境.这是一个PPICPPIC.

更多相关视频

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...