索拉 (Solanum torvum) 诱导铁致死以抑制肝细胞癌的发生
Hsiang-Chun Lai1, Jui-Chun Weng2, Hui-Chi Huang3
1Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Journal of ethnopharmacology
|August 8, 2024
概括
索兰 (Solanum torvum,ST) 诱导铁,抑制肝瘤细胞的生长. 它显示了与lenvatinib的添加效应和对抗性细胞的有效性,可能减少lenvatinib的使用.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- Solanum torvum Sw. (ST) 是一种用于治疗各种疾病的民族医学,包括瘤.
- 它的传统用途表明其潜在的抗癌性质.
研究的目的:
- 研究肝细胞癌 (HCC) 中ST诱导的铁亡的机制.
- 为了评估ST与lenvatinib的结合效果.
- 为了评估ST在抗伦瓦提尼布的HCC细胞中的疗效.
主要方法:
- 用ST治疗的肝瘤细胞系进行细胞活力测定.
- 流细胞测量用于脂质过氧化和铁检测.
- 西方涂抹用于检测铁灭菌途径分子.
- 在抗伦瓦提尼布细胞系中评估ST.
主要成果:
- 通过诱导铁亡,ST抑制了肝瘤细胞的生长.
- ST降低了谷氨过氧化酶4 (GPX4) 的表达,增加了脂质过氧化和Fe2+积累.
- 由ST诱导的铁灭症涉及血红素酶-1 (HO-1) 和长链合成酶家族成员4 (ACSL4) 的乙烯基-CoA合成酶.
- ST显示了与伦瓦提尼布的添加效应,并保留了在耐药细胞中的疗效.
结论:
- ST诱导铁,抑制肝瘤细胞的增殖.
- ST有潜力作为林瓦替尼的辅助疗法.
- ST对抗伦瓦提尼布耐药HCC的疗效被证明是有效的,这表明它在克服耐药性方面发挥了作用.
更多相关视频
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.8K
07:47Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
Published on: August 31, 2022
2.2K
相关概念视频
01:16Necrosis
4.4K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.4K
01:12Loss of Tumor Suppressor Gene Functions
4.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.7K