肝脏对食用油炸向日油的反应
Elisa V Macri1, Vanessa Touceda2, Morena Wiszniewski3
1Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Bioquímica General y Bucal, Buenos Aires, Argentina.
The Journal of nutritional biochemistry
|August 8, 2024
概括
在饮食中食用加热的向日油 (SFOx) 会增加内脏脂肪,并导致肝损伤,包括肝硬化和氧化应激,在成长中的老鼠中. 这种饮食可能导致肝纤维化.
科学领域:
- 毒理学 毒理学 毒理学
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 太阳花油是阿根廷普遍存在的脂肪来源,通常用于油炸.
- 消费反复加热的油,特别是向日油的健康影响需要调查.
研究的目的:
- 为了研究含有氧化日油 (SFOx) 的饮食对成长中的老鼠肝脏的影响.
- 评估脂质特征,血糖,内脏脂肪和肝脏组织学的变化.
主要方法:
- 39只Wistar大鼠在8周内接受了控制食,向日油 (SFO) 或氧化向日油 (SFOx) 食.
- 评估的体重,食物摄入量,内脏脂肪,肝体指数,肝脂肪酸概况,氧化应激标志物和纤维化标志物.
- 对肝脏组织进行了组织学分析.
主要成果:
- 与对照组相比,SFOx养的老鼠显示能量摄入量增加和内脏脂肪积累增加.
- 肝脏分析显示,SFOx养大鼠的和型脂肪酸,氧化物和其他氧化副产品增加.
- 在SFOx养的老鼠中观察到肝硬化,氧化应激标志物 (ROS) 升高和抗氧化能力 (催化酶活性) 降低.
结论:
- 在生长过程中饮食中摄入氧化日油可以诱导肝损伤,其特征是肝硬化和氧化应激.
- 肝脏中有毒化合物和反应性氧物种的积累可能会促进肝纤维化进一步进展.
- 这些发现突出了与消费反复加热的油相关的潜在风险.
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