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普罗基亚尼丁通过Nrf2信号通路缓解TM3细胞中双A诱导的亡

Feilong Pan¹, Wenzhe Yang¹, Tong Zhao¹

¹College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Harbin, 150030, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|August 8, 2024

概括

普罗亚尼丁 (PC) 通过减少氧化应激和亡来保护BPA诱导的莱迪格细胞损伤. PC激活了Nrf2通路,这表明它可以减轻双甲 (BPA) 毒性.

科学领域:

内分泌学在内分泌学.
毒理学毒理学毒理学
细胞生物学细胞生物学

背景情况:

在食品包装中发现的双甲 (BPA) 与生殖功能障碍有关.
需要阐明天然抗氧化剂的保护机制,如Procyanidin (PC) 对BPA诱导的莱迪格细胞损伤.

研究的目的:

研究PC对TM3莱迪格细胞中BPA诱导的损伤的保护作用.
阐明PC保护作用的基础分子机制.

主要方法:

TM3莱迪格细胞暴露于BPA,并用PC处理.
评估了氧化应激,细胞亡和Nrf2信号通路.
用NRF2抑制剂ML385来确认该途径的参与.

主要成果:

PC治疗减轻了BPA诱导的TM3细胞损伤,抑制了氧化应激和亡.
抗氧化基因对核因子红色素2相关因子2 (Nrf2) 和其抗氧化剂标基因的表达进行了上调.
抑制Nrf2可以逆转PC对基因表达的有益影响.

结论:

通过激活Nrf2信号通路,PC可以减轻BPA诱导的TM3细胞损伤.
补充PC显示了在莱迪格细胞中减轻双A (BPA) 毒性的潜力.

关键词:

BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA Nrf2 没有任何问题.氧化应激是一种氧化应激.普罗基亚尼丁是什么?生殖毒理学生殖毒理学

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