经典和非经典单细胞都在环卫淋巴细胞毛细血管,并促进急性淋巴细胞炎症
ZheHao Tan1, Pam Hall1, Matthias Mack2
1Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
The American journal of pathology
|August 8, 2024
概括
经典和非经典的单细胞都在脏的球微血管系统中巡逻. 古典单细胞,但不是非古典单细胞,在急性淋巴结核突炎期间增加巡逻,促进中性粒细胞活动.
科学领域:
- 免疫学 免疫学 免疫学
- 脏生理学 脏生理学
- 微血管动力学 微血管动力学
背景情况:
- 单细胞对血管系统的巡逻主要归因于非古典单细胞.
- 之前的研究表明,古典和非古典单细胞可以保留并迁移到球微血管结构中.
- 单细胞子集在急性淋巴细胞炎症中的独特作用仍然不清楚.
研究的目的:
- 研究质微血管中的古典和非古典单细胞的巡逻行为.
- 确定这些单细胞子集对急性中性粒细胞依赖型球炎症的贡献.
主要方法:
- 在Cx3cr1gfp/+记者小鼠中利用了球多光子内显微镜.
- 采用基因枯竭 (Csf1rCreNr4a1fl/fl小鼠) 和抗体介导枯竭 (anti-CCR2) 来消除特定的单细胞子集.
- 诱导的急性球腺炎模型,以评估中性粒细胞的反应.
主要成果:
- 经典和非经典单细胞都在球微血管结构中表现出长时间的保留和迁移.
- 经典的单细胞巡逻和迁移在急性淋巴结膜炎期间显著增加.
- 无论是古典或非古典单细胞的消耗,都会降低中性粒细胞的保留和激活在炎症质细胞中.
- 两种子集的联合消耗进一步降低了中性粒细胞活性.
- 单细胞子群枯竭在CD4+ T细胞依赖型球炎模型中没有影响中性粒细胞的反应.
结论:
- 经典和非经典单细胞都积极巡逻球微血管结构.
- 经典单细胞在急性淋巴结膜炎期间促进中性粒细胞反应方面发挥着更为突出的作用.
- 这些发现强调了单细胞子集对脏炎症的差异性贡献.
更多相关视频
09:28Imaging Neutrophils and Monocytes in Mesenteric Veins by Intravital Microscopy on Anaesthetized Mice in Real Time
Published on: November 16, 2015
10.5K
09:57Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
Published on: August 12, 2019
9.7K
相关概念视频
Inflammation
53.3K
Overview
53.3K
Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Cells of the Innate Immune Response
1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K
Classification of Leukocytes
1.8K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
1.8K
Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
