在患有酒精使用障碍的人群中,在威胁预测期间改变了有效连接性
Milena Radoman1, K Luan Phan2, Olusola A Ajilore3
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.
概括
患有酒精使用障碍 (AUD) 的人在不可预测的威胁预测期间表现出高度的胸膜岛屿连接. 这种大脑网络的差异可能会通过过度饮酒来驱动避免应对,这表明一个潜在的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 对不确定的压力因素的高反应性可能会通过避免应对驱动酒精使用障碍 (AUD).
- 参与威胁处理的关键大脑区域包括前胰岛,前中丘脑和背前环状皮层.
- 了解威胁预测期间的网络功能对于AUD研究至关重要.
研究的目的:
- 为了研究前胰岛的功能网络动态,前中丘脑和背前环状皮层.
- 为了比较AUD和健康对照个体之间的可预测和不可预测的威胁预测期间的网络连接.
- 为了确定在AUD中基于避免的应对背后的神经机制.
主要方法:
- 使用功能磁共振成像 (fMRI) 和动态因果建模 (DCM).
- 参与者包括43名患有AUD的成年人和26名健康对照者 (年龄21-30岁).
- 参数实证贝叶斯模型用于有效连接的组比较.
主要成果:
- 患有AUD的个体在不可预测的威胁预测期间显著增加了右侧中前丘脑到右侧前丘脑的投射.
- 这种增强的方向影响与AUD组的每周酒精消费相关.
- 在可预测的威胁预测期间,在网络连接方面没有观察到任何显著的群体差异.
结论:
- 这项研究是第一个在AUD中预测威胁期间展示定向前边界相互作用的研究.
- 在AUD患者中,自下而上的乳头岛内投影对于不可预测的威胁处理至关重要.
- 需要进一步的研究来确定这些神经差异和AUD之间的因果关系.
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