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在预防COVID-19中CoronaVac的有效性,这是巴西的一项检测负的病例控制研究

Expedito J A Luna¹, José C Moraes², Manuela A Roediger³

¹Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

|August 8, 2024

概括

CoronaVac疫苗在对抗症状性COVID-19的有效率为39%,在预防中度至重度疾病的有效率为91%. 这项研究突出了CoronaVac的重点.

科学领域:

* 传染病流行病学
* 疫苗学疫苗学疫苗学
* * 公共卫生公共卫生

背景情况:

*SARS-CoV-2大流行需要快速开发和评估疫苗.
*了解像CoronaVac这样的疫苗在现实世界中的有效性对于公共卫生战略至关重要.

研究的目的:

*为了评估两剂CoronaVac疫苗的有效性.
*评估SARS-CoV-2症状性疾病和中度至重度COVID-19病例的预防.

主要方法:

* 试验阴性,无匹配的病例控制研究设计.
*包括病毒学确认的症状性COVID-19病例和负测试的对照.
*数据采集于2021年3月至11月在巴西圣保罗,利用RT-PCR和疫苗接种记录.

主要成果:

* 针对COVID-19症状的调整后疫苗有效率为39.0% (95%CI为6.0-60.0%).
*预防中度和重度COVID-19的AVE为91.0% (95%CI为76.0-97.0%).
*疫苗接种情况,年龄,最近与病例接触以及教育水平与结果独立相关.

结论:

* CoronaVac疫苗在预防中度至重度COVID-19方面表现出高效.
*研究结果受到玛变种和疫苗接种覆盖率增加的影响.
*这项研究支持CoronaVac在缓解严重疾病后果方面的作用.

关键词:

巴西巴西巴西巴西.案例控制研究研究.有效性有效性.没有活化的疫苗.这就是SARS-CoV2病毒.测试结果为阴性.

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