相关实验视频

Updated: May 12, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

怀疑中枢神经系统感染的儿童细菌脑膜炎的诊断预测模型:系统性审查和前性验证研究

Nina S Groeneveld¹, Merijn W Bijlsma², Ingeborg E van Zeggeren¹

¹Department of Neurology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.

|August 8, 2024

概括

诊断预测模型有效地帮助排除疑似中枢神经系统 (CNS) 感染的儿童的细菌性脑膜炎 (BM). 这些模型的准确性很好,但应该补充,而不是取代临床评估.

科学领域:

儿童传染病儿童传染病
临床流行病学临床流行病学
诊断测试评价诊断测试评价诊断测试评价

背景情况:

细菌性脑膜炎 (BM) 在怀疑中枢神经系统 (CNS) 感染的儿童中具有重大风险.
现有的诊断预测模型旨在评估儿科患者的BM概率.

研究的目的:

在广泛的儿科人口中对细菌性脑膜炎 (BM) 的现有诊断预测模型进行外部验证.
评估这些模型在疑似中枢神经系统感染的儿童中的诊断准确性和校准.

主要方法:

在Medline的系统文献审查中,确定了BM的相关预测模型.
在450名疑似中枢神经系统感染的儿童 (0-18岁) 的前队伍中对已识别的模型进行外部验证 (2012-2015).
计算灵敏度,特异性,预测值,AUC和校准评估.

主要成果:

23个预测模型得到了验证. 17%的患者患有中枢神经系统感染,7%的患者被诊断为BM.
总体AUC在0.69到0.94之间 (中位数为0.83).
模型表现良好至优秀,特别是在28天以上的儿童中 (中位数AUC为0.89).

结论:

诊断预测模型表现出良好的到优秀的测试特征,用于排除儿科患者的BM.
这些模型可以帮助诊断疑似儿童中枢神经系统感染的诊断工作.
模型应与彻底的临床评估和辅助测试一起使用,而不是作为替代品.

关键词:

决策是做出决策的过程.诊断微生物学诊断微生物学传染病是一种传染性疾病.神经学神经学神经学

更多相关视频

Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells

Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells

Published on: July 14, 2020

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

相关概念视频

Viral Meningitis

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

Bacterial Meningitis I: Introduction

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

Bacterial Meningitis II: Pathophysiology

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...

Brain Abscess l: Introduction

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...