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Updated: Jun 17, 2025

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Published on: February 12, 2015

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DNAJA2和Hero11介导类似的TDP-43的构造延伸和聚合抑制

Andy Y W Lam1,2, Kotaro Tsuboyama1,3, Hisashi Tadakuma1,4

  • 1Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.

RNA (New York, N.Y.)
|August 8, 2024
PubMed
概括

英雄蛋白质,像分子伴侣一样,通过稳定内在无序区域的扩展形状来防止有毒蛋白质的聚合,例如TDP-43,这是ALS等神经退行性疾病的关键因素.

关键词:
英雄蛋白质 英雄蛋白质TAR DNA 结合蛋白 43 43 结合蛋白陪伴者是一个陪伴者.本质上是无序的蛋白质.单分子FRETET是一种单分子FRET.

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