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Updated: May 13, 2026

Generation of In-Frame Gene Deletion Mutants in Pseudomonas aeruginosa and Testing for Virulence Attenuation in a Simple Mouse Model of Infection
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Generation of In-Frame Gene Deletion Mutants in Pseudomonas aeruginosa and Testing for Virulence Attenuation in a Simple Mouse Model of Infection

Published on: January 8, 2020

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一种非自然的氨基酸依赖性,有条件的伪omonas疫苗可以预防细菌感染

Michael Pigula1, Yen-Chung Lai2,3, Minseob Koh4

  • 1Department of Chemistry, Scripps Research, La Jolla, CA, USA.

Nature communications
|August 8, 2024
PubMed
概括

研究人员通过使用非自然氨基酸 (UAA) 来设计一种活体细菌疫苗,以提高安全性. 这种新的疫苗策略可以防止细菌逃逸,并保护小鼠免受致命的感染.

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