在母肝中,一个协调的转录程序使用脂物向胚胎提供长链多不和脂肪酸
Risha Amarsi1,2, Samuel Furse3,4, Mary A M Cleaton5
1Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, SE19RT, UK.
Nature communications
|August 8, 2024
概括
母亲向胎儿提供长链多不和脂肪酸 (LC-PUFA) 对胎儿的发育至关重要. 一个特定的肝脏通路在怀孕后期被激活,显著增加LC-PUFA转移,特别是DHA,这对胎儿大脑生长至关重要.
科学领域:
- 生殖生物学 生殖生物学
- 孕产妇和胎儿的医学
- 营养生物化学 营养生物化学
背景情况:
- 长链和非常长链多不和脂肪酸 (LC-PUFA) 对胎儿发育至关重要.
- 母亲对LC-PUFA的转移至关重要,缺陷与死产,生长限制和神经发育问题有关.
- 饮食补充剂的有限成功表明,复杂的母胎脂肪酸供应机制.
研究的目的:
- 为了阐明母亲肝脏适应LC-PUFA转移到胎儿的分子机制.
- 研究特定信号通路在孕期调节母亲LC-PUFA供应中的作用.
- 了解受损脂质代谢对胎儿LC-PUFA积累的影响.
主要方法:
- 在小鼠模型中,对母体和胎儿组织的综合非向和向脂质组学.
- 孕产妇和胎儿组织的转录概况.
- 使用野生型和转基因小鼠模型进行比较分析,这些小鼠的脂质代谢受损.
主要成果:
- 确定了对于为胎儿提供LC-PUFA至关重要的母性肝适应.
- 证明了肝脏X受体 (LXR) 信号通路的晚期怀孕特定激活.
- 表明LXR通路的激活显著增加了母体循环中的LC-PUFA,其遗传干扰减少了胎儿LC-PUFA积累,特别是DHA.
结论:
- 在怀孕晚期,LXR信号通路在调节母亲肝脏LC-PUFA供应方面发挥着至关重要的作用.
- 准母亲的LXR信号可能代表了一种新的策略,以优化胎儿对DHA等必需脂肪酸的积累.
- 了解这些分子机制是解决与LC-PUFA缺乏相关的妊娠并发症的关键.
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